Aerobic Oxidative Cyclization of 2-Mercaptobenzamide to 1,2-Benzoisothiazolin-3-One in the Presence of Mn(OAc)2

Abstract

The full text of the article will be published in the English version of the journal "Catalysis in Industry" No. 1, 2023.

One of a widely-used broad-spectrum industrial bactericidal and mildew prevention agents is 1,2-benzoisothiazolin-3-one (BIT). In present study, it was demonstrated that aerobic oxidative cyclization of 2-mercaptobenzamide (MBA) and 2,2’-disulfanediyldibenzamide (DSBA) in the presence of Mn(OAc)2 as catalyst allowed to obtain BIT. The mechanism reaction was suggested. It was found that DSBA and MBA can be converted to the BTI with 99 % yield at 1.0 mol.% Mn(OAc)2 under 0.3 MPa of O2 and 100 °C for 8 h. Experimental data point that this protocol is both economical and environmentally friendly.